Day 1
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KEYNOTE PRESENTATION Advancing Diagnostics with Digital Detection: From Quantifying Ultra-Rare Mitochondrial DNA Mutations to Profiling Tumor-Infiltrating Lymphocytes Jason H. Bielas, Ph.D., Associate Member, Translational Research Program, Fred Hutchinson Cancer Research Center (FHCRC); Affiliate Assistant Professorship, Department of Pathology, University of Washington
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In addition to precise quantification of nucleic acids, there are a number of advantages that digital PCR affords over other detection methods. I will discuss these advantages and review a number of novel digital PCR-dependent assays, which we have developed in our laboratory.
PCR MEASUREMENT AND ANALYSIS
Reverse Transcription Digital PCR Stephen Bustin, BA(Mod), Ph.D., FSB, Professor, Molecular Medicine, Postgraduate Medical Institute, Faculty of Medical Sciences, Anglia Ruskin University
Digital PCR Standards Ross Haynes, Biological Science Technician, Biochemical Science Division, National Institute of Standards and Technology (NIST)
Defining Reference Standards for Digital PCR and Demonstrating Their Application in Circulating Tumor Assay Development Jonathan Frampton, Ph.D., Global Product Manager,Horizon Diagnostics
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Corporate Sponsor
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Analysis and Visualization of Digital PCR Experiments - Applications of the dpcR Framework Stefan Rödiger, Ph.D., Group Leader, InnoProfile, "Image-Based Assays", Brandenburg University of Technology
A Robust Framework for Digital PCR Data Analysis Jo Vandesompele, Ph.D., CEO, Biogazelle; Professor, Ghent University
Day 2
dPCR FOR PATIENT MONITORING AND STRATIFICATION
Digital PCR for Patient Monitoring and Stratification in Clinical Trials Reinhold Pollner, Ph.D., Director, Clinical Trial Assay Development, Genoptix Medical Laboratory, a Novartis Company
Evaluation of EGFR Mutations in Plasma from NSCLC Patients: Utility in Managing Patients on TKI Therapy Chris Karlovich, Ph.D., Principal Scientist, Molecular Diagnostics, Clovis Oncology
Serial Monitoring of EGFR Mutations in Plasma and Matched Tissue from EGFR Mutant Non-Small Cell Lung Cancer Patients on Erlotinib Cloud P. Paweletz, Ph.D., Head, Translational Research Laboratory; Biomarker Lead, Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute
MINORITY TARGET DETECTION
Digital PCR for Detecting Rare Genomic Alterations which Enhances Sensitivity in Cell-Free DNA Rachel Tam, Senior Research Associate, Clinical Assay Development, Oncology Biomarker Development, Genentech, Inc.
Applications of Digital PCR in Oncology: Detecting Residual Disease in Plasma of Early Stage Breast Cancer Patients and Archival Tissue Studies Using Droplet Digital PCR Rory L. Cochran, Ph.D. Candidate, Ben Ho Park Lab, Graduate Program in Cellular & Molecular Medicine, Johns Hopkins University School of Medicine
COPY NUMBER VARIATION
Sponsored Presentation Speaker to be Announced |
Corporate Sponsor
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Development of Configurable Genotyping Assays for Single Color Digital PCR in Cancer Hanlee P. Ji, M.D., Assistant Professor, Medicine, Division of Oncology, Stanford University School of Medicine
Evaluation of Genetic Stability of HSV Transgenes in a Constructed Vero Cell Line Ali Azizi, Ph.D., Scientist, Adjunct Professor, Microbiology and Virology, Analytical Research and Development, sanofi pasteur
Sponsored Presentation Speaker to be Announced |
Corporate Sponsor
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Statistical Modeling Techniques for Setting Digital PCR-Based Quality Control Specifications Douglas Sanders, Ph.D., Senior Scientist, Companion Diagnostics, Novartis
Day 3
Panel Discussion with Technology Vendors: Digital PCR Implementation Considerations Moderator: Ross Haynes, Biological Science Technician, Biochemical Science Division, National Institute of Standards and Technology (NIST)
Panelists will include representatives from:
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Bio-Rad
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Horizon Diagnostics
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Life Technologies
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Sysmex Inostics GmbH
ABSOLUTE QUANTIFICATION
The Application of Digital PCR to Infectious Disease Detection Jim Huggett, B.Sc. (Hons), Ph.D., Science Leader, Nucleic Acid Metrology, Molecular & Cell Biology, LGC
dPCR and Beyond: Clinical Utility of Cell-Free Tumor DNA Frank Holtrup, Ph.D., Head, R&D Service Laboratories,Sysmex Inostics GmbH |
Corporate Sponsor
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NGS-Assisted DNA-Based Digital PCR for the Detection and Quantification of Residual Disease in CML Patients with Undetectable BCR-ABL1 Transcripts Mary Alikian, Imperial Molecular Pathology, Imperial Healthcare Trust, Hammersmith Hospital; Centre for Haematology, Faculty of Medicine, Imperial College London
Diagnostic Use of Digital PCR for Liquid Biopsy Ekkehard Schütz, M.D., Ph.D., CTO, Senior Vice President, Research, Chronix Biomedical, Inc.
EMERGING DIGITAL BIOLOGY TECHNOLOGIES
Featured Poster Presentations Two posters outlining a new techonology or technique will be selected by the Scientific Advisory Board and the authors will be invited to give a 15-minute presentation on their work. Deadline to submit a poster is September 5, 2014. Full details.
On-Chip Integrated Digital PCR Technologies Abraham "Abe" Lee, Ph.D., William J. Link Professor and Chair, Department of Biomedical Engineering, Director, Micro/Nano Fluidics Fundamentals Focus (MF3) Center, University of California, Irvine
PACS: PCR-Activated Cell Sorting Adam R. Abate, Ph.D., Assistant Professor, Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco
The Amplinome Test: A Pan-Cancer Droplet Digital PCR (ddPCR) Based Assay Panel to Assess Gene Amplification Status in Solid Tumors Austin P. So, Ph.D., Director, Research & Development, TOMA Biosciences
RECOMMENDED SHORT COURSES*
Digital PCR Experiment Design and Primer Instructor: Jim Huggett, B.Sc. (Hons), Ph.D., Science Leader, Nucleic Acid Metrology, Molecular & Cell Biology, LGC October 6, 9:00AM - 12:00PM
This course will introduce the concept of digital PCR (dPCR) and explain how it compares to other molecular methodologies, citing both advantages and disadvantages. Included in the discussion will be the application of dPCR to perform minority target detection, absolute quantification and measurement of copy number variation as well as the analysis of RNA using reverse transcriptase dPCR. The discussion will also include some of the specific challenges associated with performing this technique.
Dinner Short Course: Single-Cell Genomic Analysis Instructor: Daniel T. Chiu, Ph.D., A. Bruce Montgomery Professor, Chemistry; Endowed Professor, Analytical Chemistry; Professor, Bioengineering, University of Washington, Seattle October 7, 6:00PM -8:00PM
* Separate registration required
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SPONSOR & EXHIBITOR OPPORTUNITIES
Opportunities include podium presentations available within the conference agenda, invitation only VIP dinners, Exhibit space, and more! For more details contact Jay Mulhern, Business Development Manager at 781-972-1359 or jmulhern@healthtech.com
View Final Agenda |Sponsor & Exhibit | Present a Poster | Register by July 18 & SAVE up to $400!
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